Cell Line Origin

Human, Cancer Cells

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Squamous cell carcinoma of the head and neck (HNSCC) represents 90% of all head and neck cancers (1). HNSCC is the 9th-most common cancer worldwide and is characterized by a high rate of recurrence after therapy, with a median 5-year survival range of 40-50% (1). Radiation resistance can arise when cells undergo sublethal damage during x-ray treatment, giving rise refractory post-treatment tumors with poor prognosis (2). Cellular models of HNSCC that demonstrate radiation-resistance are critical for elucidating factor associated with radio-resistance and advancing effective therapies.The SQ-20B human laryngeal squamous cell carcinoma cell line is a widely used model for radiation-resistant HNSCC. SQ-20B cells were derived from a laryngeal tumor (tumor stage 2 node stage 0) that presented following primary radiation therapy (2). The SQ-20B cell line harbors the c-raf proto-oncogene (3) associated with tumorigenicity and radio-resistance (4). SQ-20B cells have been characterized by expression of the SCC marker p63 (p40) (5). The characteristics of the SQ-20B cell line demonstrate its utility as a model for cellular mechanisms that give rise to radiation resistance.﹤bold>Source:﹤/bold>The SQ-20B cell line was derived from a tumor on the larynx of a patient undergoing radiation therapy2 and harbors a male karyotype (3).Research Category:Cancer

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact [email protected].

Packaging

≥1X10⁶ cells/vial

Storage and Stability

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.